- "One of the most vile vaults that i have seen. Walls coated in human flesh, rooms filled with horrors, begging for their lives to end..."
- ―The Explorer on Vault 72
|Inhabitants||Vault 72 Intelligent Super Mutants (2277), Intelligent Vixens (2287)|
Vault 72 was advertised across the country, for a better future for twins. However, unbeknownst of the twins, one month after the vault was sealed, one half of the twins were abducted by Vault Security, and were promptly be experimented with a new strain of FEV. Every day after that, a half of the twins would be taken and be experimented on.
Vault 72 was constructed in January of 2258, one month ahead of schedule. When the bombs dropped, and the four nukes hit the city of Rochester, 150 twins entered the vault, and the door was sealed, protecting the new vault dwellers from nuclear fire.